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Nuclear Magnetic Resonance Spectroscopic Studies of the Interaction of Phospholipids with Cholesterol

Nature volume 211, pages 1304–1305 (1966)Cite this article

Abstract

PHOSPHOLIPIDS are important constituents of cell membranes and constitute up to 40 per cent of the dry weight of the brain. We are at present studying the properties of these molecules, using a variety of physical techniques1 including nuclear magnetic resonance spectroscopy. This is a particularly useful technique since broad line nuclear magnetic resonance spectroscopy can be used for studying molecular motion in the solid and liquid crystalline condition2, and high resolution techniques3 can be used to study the detailed interactions of these molecules.

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References

  1. Chapman, D., Byrne, P., and Shipley, G. G., Proc. Roy. Soc., A, 290, 115 (1966).

    Article  ADS  CAS  Google Scholar 

  2. Chapman, D., and Salsbury, N. J., Proc. European Molecular Spectroscopy Conference (1965).

    Google Scholar 

  3. Chapman, D., and Morrison, A., J. Biol. Chem. (in the press).

  4. Fleischer, S., and Brierley, G., Biochem. Biophys. Res. Commun., 5, 357 (1961).

    Google Scholar 

  5. Leathes, J. B., Lancet, 208, 853, 957, 1019 (1925).

    Article  Google Scholar 

  6. van Deenen, L. L. M., Houtsmuller, V. M. T., de Haas, G. H., and Mulder, E., J. Pharm. and Pharmacol., 14, 429 (1962).

    Article  CAS  Google Scholar 

  7. Saunders, L., Perrin, J., and Gammack, D., J. Pharm. and Pharmacol., 14, 567 (1962).

    Article  CAS  Google Scholar 

  8. Dervichian, D. G., Prog. Biophys. Molec. Biol., 14, 263 (1964).

    Article  CAS  Google Scholar 

  9. Jardetzky, O., Adv. Chem. Phys., 9, 499 (Interscience, London, 1964).

    Google Scholar 

  10. Chapman, D., Ann. N.Y. Acad. Sci., 137, 745 (1966).

    Article  ADS  CAS  Google Scholar 

  11. Finean, J. B., Exp. Cell Res., 5, 18 (1958).

    Google Scholar 

  12. Vandenheuvel, F. A., J. Amer. Oil Chem. Soc., 40, 455 (1963).

    Article  Google Scholar 

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Authors and Affiliations

  1. Molecular Biophysics Unit, Unilever Research Laboratory, The Frythe, Welwyn, Herts

    D. CHAPMAN & S. A. PENKETT

Authors
  1. D. CHAPMAN
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  2. S. A. PENKETT
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CHAPMAN, D., PENKETT, S. Nuclear Magnetic Resonance Spectroscopic Studies of the Interaction of Phospholipids with Cholesterol. Nature 211, 1304–1305 (1966). https://doi.org/10.1038/2111304a0

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