Abstract
THE function of viral neuraminidase (N-acetylneuraminate glycohydrolase, EC 3.2.1.18) during the reproductive cycle of myxoviruses is not yet clearly defined. It was therefore considered that potent inhibitors might be utilized to gain further insight into the role of this enzyme. In experiments involving the interaction of myxoviruses with phosphotungstic acid, it has been found that this compound is a potent inhibitor of neuraminidases at extremely low concentrations. A closer examination of this phenomenon revealed that the anionic character of this substance is responsible for the effect. Different polyanions were tested and some of them were found to be even more effective inhibitors of neuraminidase.
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DRZENIEK, R. Inhibition of Neuraminidase by Polyanions. Nature 211, 1205–1206 (1966). https://doi.org/10.1038/2111205a0
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DOI: https://doi.org/10.1038/2111205a0
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