Abstract
WE have previously shown that native homologous deoxyribonucleic acids (DNAs) can be used as therapeutic agents in irradiated animals. We showed that, for example, native homologous testes DNA significantly increases the percentage of survival of infantile rats and mice (8 and 17 days old), irradiated with a dose of 600 r.1. Furthermore, we obtained a positive therapeutic effect in infantile rats of the same age injected with liver DNA after irradiation with a dose of 600 r.2. Our results showed that other DNAs, such as those from thymus and spleen, can increase the survival from radiation disease3. We also showed that these homologous native DNAs from various organs not only increase the proportion surviving radiation disease, but also support the regeneration of function in the reproductive organs of irradiated immature male rats. The percentage of fertile rats is significantly higher (60–70 per cent) in animals treated with DNA (isolated from various organs) after irradiation, than in control animals (25–30 per cent)3,4.
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SAVKOVIČ, N., KAČAKI, J. & HAJDNUKOVIČ, S. Recovery Effect of Heterologous Deoxyribonucleic Acid from Various Organs on Irradiated Mice. Nature 211, 1179–1180 (1966). https://doi.org/10.1038/2111179b0
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DOI: https://doi.org/10.1038/2111179b0
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