Abstract
RECENTLY, the aggregation of sRNA from Escherichia coli has been reported1. At neutral pH and at 25° C the aggregation process is dependent on nucleic acid and magnesium ion concentration. In 0.02 M magnesium, the aggregates dissociate into monomer units at low nucleic acid concentrations. This report shows that a modest increase in temperature (from 25° C to 45° C) partially dissociates the aggregates and that the decrease in molecular weight is reflected in the viscosity thermal profile.
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References
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MILLAR, D. Effect of Temperature on s-Ribonucleic Acid Aggregation induced by Magnesium Ions. Nature 211, 1088–1089 (1966). https://doi.org/10.1038/2111088b0
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DOI: https://doi.org/10.1038/2111088b0
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