Abstract
THE uptake and alteration of oxytetracycline (OTC) has been demonstrated with the ascomycete Xylaria digitata1. So far as we can trace, no reports have been published concerning the fate of this drug in bacteria. Izaki and Arima2,3 have investigated the uptake and accumulation of OTC by Escherichia coli K12. They have reported that large amounts of the antibiotic are retained by the cells, but the chemical nature of the intracellular OTC was not investigated.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Meyers, E., and Smith, D. A., J. Bacteriol., 84, 797 (1962).
Arima, K., and Izaki, K., Nature, 200, 192 (1963).
Izaki, K., and Arima, K., Nature, 200, 384 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LAST, J., SNELL, J. Microbiological Transformation of Oxytetracycline. Nature 211, 1002–1003 (1966). https://doi.org/10.1038/2111002b0
Issue Date:
DOI: https://doi.org/10.1038/2111002b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.