Abstract
WHEN an animal is subjected to prolonged immunization with ribosomes (of whatever origin), its serum becomes progressively endowed with NG I antibodies*, which specifically precipitate various types of RNA and all the synthetic polyribonucleotides so far tested1,2,4. On the other hand, these sera and the sera of animals not immunized against ribosomes both contain NG II globulins3: these factors precipitate poly-I and poly-U only; however, the reaction is specifically inhibited by various RNAs (and by either poly-A or poly-C) but not by DNA. We have reason to believe that NG II factors in equine serum are antibodies which belong to the 7S globulin fraction recently described by Sandor et al.5. However, we have previously shown that the sera of animals not immunized against ribosomes contain these factors in amounts of from ten to twenty times less than those found in immunized animals3.
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References
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PANIJEL, J., CAYEUX, P., SACQUET, E. et al. Anti-ribonucleic Acid Factors in the Sera of Germ-free Animals. Nature 211, 94–96 (1966). https://doi.org/10.1038/211094a0
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DOI: https://doi.org/10.1038/211094a0
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