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Ultrastructural Aspects of Duodenal Crypts in X-irradiated Mice after Chemical Protection

Nature volume 210, pages 749–750 (1966)Cite this article

Abstract

AFTER X-irradiation the cells of the duodenal crypt of the mouse show morphological alterations which have been described with the help of optic and electronic microscopy1,2. The protective effect of aminoethyl-isothiourea (AET) on the intracellular structures of the irradiated duodenum has already been shown3. Recently, it was demonstrated by different authors that a mixture of certain radioprotectors was more effective than each alone4,5 and even allowed an increase of the L.D. 100/30 by a factor of 2.4 (ref. 6). With these results in mind, we have investigated the ultrastructural aspects of the duodenal crypt after irradiation of mice protected by a mixture of glutathione, AET and serotonin.

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References

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Authors and Affiliations

  1. Laboratoire de Microscopie Electronique, Département de Radiobiologie, Centre d'Etude de l'Energie Nucléaire, Mol, Belgium

    J. HUGON, J. R. MAISIN & M. BORGERS

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  1. J. HUGON
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  2. J. R. MAISIN
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  3. M. BORGERS
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HUGON, J., MAISIN, J. & BORGERS, M. Ultrastructural Aspects of Duodenal Crypts in X-irradiated Mice after Chemical Protection. Nature 210, 749–750 (1966). https://doi.org/10.1038/210749a0

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