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Demonstration of Circulating Antibodies to Plasmodium falciparum by Gel-diffusion Techniques

Abstract

As age advances, Africans resident in hyperendemic regions of The Gambia, West Africa, acquire a marked ability to limit malarial parasitaemia1. IgG (7 S gamma-globulin) prepared from the sera of adult Gambians exerts a profound anti-plasmodial effect about the time of schizogony when administered to young children experiencing heavy Plasmodium falciparum infection2. .Recently, using antigen preparations of locally acquired P. falciparum, we have been able to demonstrate, by gel-diffusion techniques, the existence of precipitating antibody in the sera of Gambians believed to be immune to malaria.

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MCGREGOR, I., HALL, P., WILLIAMS, K. et al. Demonstration of Circulating Antibodies to Plasmodium falciparum by Gel-diffusion Techniques. Nature 210, 1384–1386 (1966). https://doi.org/10.1038/2101384a0

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