Abstract
As age advances, Africans resident in hyperendemic regions of The Gambia, West Africa, acquire a marked ability to limit malarial parasitaemia1. IgG (7 S gamma-globulin) prepared from the sera of adult Gambians exerts a profound anti-plasmodial effect about the time of schizogony when administered to young children experiencing heavy Plasmodium falciparum infection2. .Recently, using antigen preparations of locally acquired P. falciparum, we have been able to demonstrate, by gel-diffusion techniques, the existence of precipitating antibody in the sera of Gambians believed to be immune to malaria.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
McGregor, I. A., and Smith, D. A., Trans. Roy. Soc. Trop. Med. Hyg., 46, 403 (1952).
Cohen, S., McGregor, I. A., and Carrington, S., Nature, 192, 733 (1961).
Zuckerman, A. (personal communication).
Spira, D., and Zuckerman, A., Science, 137, 536 (1962).
Hughes, D. E., Brit. J. Exp. Path., 32, 97 (1951).
McGregor, I. A., Williams, K., Voller, A., and Billewicz, W. Z., Trans. Roy. Soc. Trop. Med. Hyg., 59, 395 (1965).
Thurston, J. R., Rheins, M. S., and Buehler, E. V., J. Lab. Clin. Med., 49, 647 (1957).
Ouchterlony, Ö., Acta Pathol. Microbiol. Scand., 26, 507 (1949).
Coggeshall, L. T., Medicine, 22, 87 (1943).
McGregor, I. A., Amer. J. Trop. Med. Hyg., 13, 237 (1964).
Brown, K. N., and Brown, I. N., Nature, 208, 1286 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MCGREGOR, I., HALL, P., WILLIAMS, K. et al. Demonstration of Circulating Antibodies to Plasmodium falciparum by Gel-diffusion Techniques. Nature 210, 1384–1386 (1966). https://doi.org/10.1038/2101384a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/2101384a0
This article is cited by
-
Immunologic aspects of renal lesions associated with malaria
Kidney International (1979)
-
In vitro Growth of Plasmodium knowlesi and P. falciparum
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.