Abstract
DURING investigations of the controlled inactivation of pyridoxal phosphate-dependent enzymes, an acid phosphatase preparation has been used to effect co-enzyme destruction. Alkaline phosphatases of mammalian origin are known to hydrolyse both pyridoxal and pyridoxamine phosphates1,2 and an alkaline phosphatase preparation from E. coli has been used for the resolution of tryptophanase3. A preliminary report on the inactivation of L-α-alanine : phenylglyoxal transaminase by treatment with alkaline phosphatase has also appeared4. The breakdown of vitamin B6 phosphates by acid phosphatases does not appear to have previously been reported.
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ANDREWS, M., TURNER, J. Pyridoxal and Pyridoxamine Phosphate Breakdown by an Acid Phosphatase Preparation. Nature 210, 1159 (1966). https://doi.org/10.1038/2101159a0
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DOI: https://doi.org/10.1038/2101159a0
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