Abstract
Mandel, Cambosos and Smith1 have reported that appreciable amounts of acetylsalicylic acid can be present in human plasma and that it may be detected for up to 2 h after its oral administration. Also, from the work of Davison and Smith2, the plasma proteins may bind acetylsalicylic acid to a much smaller extent than salicylic acid, thus making a greater proportion available for excretion. It should, therefore, be expected that some acetylsalicylic acid will be excreted in the urine.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mandel, H. G., Cambosos, N. M., and Smith, P. K., J. Pharmacol. and Exp. Therap., 112, 495 (1954).
Davison, C., and Smith, P. K., J. Pharmacol. and Exp. Therap., 133, 161 (1961).
Pitini, G., Arch. Farm. Sper., 29, 113 (1920).
Devrient, W., Arch. exp. Path. Pharmak., 90, 242 (1921).
Hanzlik, P. J., and Presho, E., J. Pharmacol. and Exp. Therap., 21, 247 (1923).
Quick, A. J., J. Biol. Chem., 101, 457 (1933).
Bastide, P., Ann. Biol. Clin., 12, 518 (1954).
Gänshirt, H., and Malzacher, A., Arch. Pharm., 293, 925 (1960).
Brodie, B. B., Udenfriend, S., and Coburn, A. F., J. Pharmacol. and Exp. Therap., 80, 114 (1944).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CUMMINGS, A., KING, M. Urinary Excretion of Acetylsalicylic Acid in Man. Nature 209, 620–621 (1966). https://doi.org/10.1038/209620a0
Issue Date:
DOI: https://doi.org/10.1038/209620a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
