Abstract
SINCE the 1962 report by Bucha et al.1, who described the herbicidal activity of certain uracils substituted in the 3 and 6 positions, one of this class of chemicals, 5-bromo-3-sec-butyl-6-methyluracil (bromacil), has gained wide acceptance as an industrial herbicide. Investigations of the mode of action of this herbicide2,3 have shown that it is a potent direct inhibitor of photosynthesis acting at the chloroplast level. The chemical analogy between 5-bromouracil and the foregoing 3,6-substituted 5-bromouracil suggested the possibility that it might be incorporated into DNA and thereby act as a mutagen. McGahen and Hoffmann4,5 were unable to demonstrate incorporation of 5-bromo-3-sec-butyl-6-methyluracil (IV) either into the DNA of a thymineless Escherichia coli (15Tâ) or into mouse liver DNA under conditions in which 5-bromouracil (5-BU) was incorporated. Their investigations, however, did not rule out the possibility of indirect mutagenic activity. The subject of this report is a comparison of the effects of 5-BU and 5-bromouracils with several different alkyl substituents at the 3 and/or 6 positions on the back-mutation of an aminopurine-induced rII mutant of coliphage T4.
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References
Bucha, H. C., Cupery, W. E., Harrod, J. E., Loux, H. M., and Ellis, L. M., Science, 137, 537 (1962).
Hilton, J. A., Monaco, T. J., Moreland, D. E., and Gentner, W. A., Weeds, 12, 129 (1964).
Hoffmann, C. E., McGahen, J. W., and Sweetser, P. B., Nature, 202, 577 (1964).
McGahen, J. W., and Hoffmann, C. E., Nature, 199, 810 (1963).
McGahen, J. W., and Hoffmann, C. E., Nature, 200, 571 (1963).
Freese, Ernst, Proc. U.S. Nat. Acad. Sci., 45, 622 (1959).
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McGAHEN, J., HOFFMANN, C. Absence of Mutagenic Effects of 3- and 6-Alkyl-5-bromouracil Herbicides on a Bacteriophage. Nature 209, 1241â1242 (1966). https://doi.org/10.1038/2091241a0
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DOI: https://doi.org/10.1038/2091241a0
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