Abstract
THE physiological function of plasma, or non-specific, cholinesterase, although receiving some attention1, has not been established. This report deals with the possibility of its role as a regulator of free choline in the plasma. Several experiments were conducted in vitro to determine: (1) the inhibitory effects of free choline on the synthesis of acetylcholine and the activity of serum cholinesterase; (2) whether acetyl-S-coenzyme A (AcCoA) and choline acetylase were capable of synthesizing acetylcholine from another choline ester.
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References
Clitherow, J. W., Mitchard, M., and Harper, N. S., Nature, 199, 1000 (1963).
Nachmansohn, D., and John, H. M., J. Biol. Chem., 158, 157 (1945).
Nachmansohn, D., Hestrin, S., and Voripaieff, H., J. Biol. Chem., 180, 875 (1949).
Oliver, W. T., and Funnell, H. S., Amer. J. Vet. Res., 24, 32 (1963).
Stadtman, E. R., in Methods in Enzymology, edit. by Colowick and Kaplan, 3, 935 (Academic Press Inc., New York, 1959).
Kalow, W., and Lindsay, H. A., Canad., J. Biochem. Physiol., 33, 568 (1955).
Bligh, J., J. Physiol., 117, 234 (1952).
MacIntosh, F. C., Canad. J. Biochem. Physiol., 41, 2555 (1963).
Oki, Y., Oliver, W. T., and Funnell, H. S., Nature, 203, 605 (1964).
Oki, Y., Oliver, W. T., and Funnell, H. S., Canad. J. Physiol. Pharmacol. (in the press).
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FUNNELL, H., OLIVER, W. Proposed Physiological Function for Plasma Cholinesterase. Nature 208, 689–690 (1965). https://doi.org/10.1038/208689a0
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DOI: https://doi.org/10.1038/208689a0
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