Abstract
USING a fly bioassay technique, Kunze and Laug1 reported the presence of toxicant in liver, kidney, abdominal fat and urine of rats fed dieldrin or aldrin. They observed that the toxicant in kidney and urine occurred mainly in males, with traces only in females. This toxicant in male kidney and urine differed from either dieldrin or aldrin because it could be readily destroyed by treatment with 2 per cent alcoholic KOH, a property not shared by the parent substances. Since these observations, a number of investigators2–6 have reported findings which indicate the presence of derivations of dieldrin and aldrin in tissues and urine. These are assumed to be metabolites and can be most readily distinguished from dieldrin and aldrin by their increased hydrophilic properties.
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References
Kunze, F. M., and Laug, E. P., Fed. Proc., 12, Abstr. No. 1117, 339 (1953).
Korte, F., Ludwig, G., and Vogel, J., Liebigs Ann. Chem., 656, 135 (1962).
Ludwig, G., Weis, J., and Korte, F., Life Sciences, 123, 3 (1964).
Cueto, jun., C., and Hayes, jun., W. J., J. Agric. Food Chem., 10, 366 (1962).
Heath, D. F., Radioisotopes and Radiation in Entomology, 63 (Intern. Atomic Energy Agency, Vienna, 1962).
Morsdorf, K., Ludwig, G., Vogel, J., and Korte, F., Medicina Experimentals, 8, 90 (1963).
Bann, J. M., DeCino, T. J., Earle, N. W., and Sun, Y. P., J. Agric. Food Chem., 4, 937 (1956).
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DATTA, P., LAUG, E., WATTS, J. et al. Metabolites in Urine of Rats on Diets containing Aldrin or Dieldrin. Nature 208, 289–290 (1965). https://doi.org/10.1038/208289a0
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DOI: https://doi.org/10.1038/208289a0
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