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Enzymatic Synthesis of Cyclo propane Fatty Aldehydes

Nature volume 206, pages 1253–1254 (1965)Cite this article

Abstract

FATTY aldehydes containing a cyclopropane ring have been isolated after acid methanolysis of the phospholipids obtained from Clostridium butyricum. 36 per cent by weight of the fatty aldehydes contained a cyclopropane ring1,2. Zalkin et al.3 and Chung and Law4 have shown that cyclopropane fatty acids are formed by the addition of a methyl group from S-adenosylmethionine to an unsaturated fatty acid moiety of phosphatidylethanolamine. An enzyme which catalyses this addition has been purified from extracts of C. butyricum4,5 The vinyl ether-linked, aldehydogenic chains in C. butyricum plasmalogens can be derived from exogenous fatty acids and fatty acid precursors, presumably by way of the normal pathways for fatty acid synthesis2.

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Author information

Author notes

  1. ALBERT E. CHUNG

    Present address: University of Colorado, Department of Biochemistry, School of Medicine, Denver, Colorado

Authors and Affiliations

  1. Department of Chemistry, Harvard University, Cambridge, Massachusetts

    ALBERT E. CHUNG

  2. Department of Bacteriology and Immunology, Harvard Medical School, Boston, 15, Massachusetts

    HOWARD GOLDFINE

Authors
  1. ALBERT E. CHUNG
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  2. HOWARD GOLDFINE
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CHUNG, A., GOLDFINE, H. Enzymatic Synthesis of Cyclo propane Fatty Aldehydes. Nature 206, 1253–1254 (1965). https://doi.org/10.1038/2061253c0

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