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Isolation of an Unknown Component from Hydrolysates of Elastin

Nature volume 205, pages 802–803 (1965)Cite this article

Abstract

PARTRIDGE et al.1 have described two new polyfunctional amino-acids obtained as products of an acid hydrolysis of bovine elastin. Compounds of identical nature were also obtained by us2. These substances, designated desmosine and isodesmosine by Partridge et al., have been shown by these investigators to contain a pyridine nucleus with amino-acid substituents on both carbon and nitrogen atoms of the ring3. The special significance of desmosine and isodesmosine is that they appear to be involved in the cross-linking of polypeptide chains of elastin1.

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References

  1. Partridge, S. M., Elsden, D. F., and Thomas, J., Nature, 197, 1297 (1963).

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  2. Franzblau, C., Sinex, F. M., Faris, B., and Smakula, E., Abstr. 145th Meeting Amer. Chem. Soc., New York, 57C (1963).

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  3. Thomas, J., Elsden, D. F., and Partridge, S. M., Nature, 200, 651 (1963).

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  4. Hamilton, P. B., Anal. Chem., 35, 2055 (1963).

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Authors and Affiliations

  1. Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts

    C. FRANZBLAU, F. M. SINEX & B. FARIS

Authors
  1. C. FRANZBLAU
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  2. F. M. SINEX
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  3. B. FARIS
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FRANZBLAU, C., SINEX, F. & FARIS, B. Isolation of an Unknown Component from Hydrolysates of Elastin. Nature 205, 802–803 (1965). https://doi.org/10.1038/205802a0

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