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Disruption of Mast Cells by a Component of Eosinophil Granules

Nature volume 205, pages 599–600 (1965)Cite this article

Abstract

EOSINOPHILS are phagocytic cells, and granules adjacent to the phagocytic vacuolo rupture1. Eosinophil granules contain a number of acid hydrolases together with basic protein and peroxidase2 and during phagocytosis these substances are discharged from the disrupted granules into, or alongside, the phagocytic vacuole. The acid hydrolases released from eosinophil granules probably have a digestive function, but the significance of the other granule components is not known. This work reports the presence in eosinophil granules of a substance capable of causing the disruption of mast cells. The active principle appears to be associated with the enzyme peroxidase.

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Authors and Affiliations

  1. New South Wales Red Cross Blood Transfusion Service, Sydney

    G. T. ARCHER & MATOULA JACKAS

Authors
  1. G. T. ARCHER
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  2. MATOULA JACKAS
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ARCHER, G., JACKAS, M. Disruption of Mast Cells by a Component of Eosinophil Granules. Nature 205, 599–600 (1965). https://doi.org/10.1038/205599a0

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