Abstract
IN the rabbit's skin chronically treated with croton oil a remarkable change is observed in the ratio between hyaluronic acid and chondroitin sulphuric acid, the former largely prevailing over the latter after one month's treatment; the same change occurs when the skin is treated with carcinogenic substances1. These data supplement what is already known about the presence of mucopolysaccharides in inflammatory processes (see, for references up to 1959, Delaunay and Bazin2 and, more recently, Berenson and Dalferes3, White et al.4, Zonta et al.5). So far as we know, no data are available concerning the changes induced in the metabolism of mucopolysaccharides by those stimuli which elicit inflammation. The present work was concerned with the dynamics of the metabolism of acid mucopolysaccharides of the rabbit's skin treated for short periods of time with croton oil, evaluating the incorporation into them of glucose (as glucosamine and galactosamine).
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References
Prodi, G., Brit. J. Cancer, 17, 504 (1963).
Delaunay, A., and Bazin, S., Bull. Assoc. Diplomés de Microbiologie de la Faculté de Pharmacie de Nancy, 75 (1959).
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White, B. N., Shetlar, M. R., and Schilling, J. A., Ann. N.Y. Acad. Sci., 94, 297 (1961).
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Alberigi-Quaranta, A., Righini, B., Prodi, V., and Rimondi, O., Nuclear Instruments and Methods, 14, 13 (1961).
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PRODI, G., LASCHI, R. Metabolism of Acid Mucopolysaccharides of the Rabbit's Dermis following Skin Treatment with Irritating Substances. Nature 205, 184 (1965). https://doi.org/10.1038/205184a0
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DOI: https://doi.org/10.1038/205184a0
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