Abstract
DURING an investigation of the known antidepressant imipramine (‘Tofranil’), this drug was not found to inhibit amino-oxidase, which indicated that this enzyme is not a pre-requisite for antidepressant action1,2. The possibility has been raised that imipramine exerts its antidepressive effect by sensitization of a central nervous adrenergic mechanism3. Later experiments have shown that among a variety of drugs imipramine markedly reduced in vivo concentration of administered tritiated noradrenaline in the heart, spleen and adrenal gland, and concomitantly elevated the plasma level of administered tritiated noradrenaline for the first 5 min. These two facts probably reflected the inhibition of the uptake of catecholamine by tissue caused by imipramine4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pletscher, A., and Gey, K. T., Helv. Physiol. Acta, 17, C 35 (1959).
Pulver, R., Exer, R., and Herrmann, B., Arzneim.-Forsch., 10, 530 (1959).
Sigg, E. B., Canad. Psychiat. Assoc. J., 4, S 75 (1959).
Herttling, G., Axelrod, J., and Whitby, G., J. Pharmacol. Exp. Themp., 134, 146 (1961).
Gordon, jun., R. S., and Charkes, A., Proc. Soc. Exp. Biol. and Med., 97, 150 (1958).
Metyšová, J., Metyš, J., and Votava, Z., Arch. Intern. Pharmacodyn., 144, 481 (1963)
Protiva, M., Hněvsová-Seidlová, V., Vejdělek, Z. J., Jirkovskyé, J., Votava, Z., and Metyšová, J., J. Med. Pharm. Chem., 4, 411 (1961).
Metyšová, J., Metyš, J., and Votava, Z., Arzneim.-Forsch., 13, 1039 (1963).
Vinařová, M., Néhunek, K., Vencovský, E., Baštecký, J., and Hádík, J., Activ. Nerv. Super. (Prague), 4, 227 (1962).
Vinař, O., and Grof, P., Activ. Nerv. Super. (Prague), 6, 179 (1964).
Vencovský, E., Šedivec, V., Peterová, E., Janovský, F., and Dvořáková, M., Activ. Nerv. Super. (Prague), 6, 177 (1964).
Dole, V. P., and Meinertz, H., J. Biol. Chem., 235, 2595 (1960).
Sulser, F., Watts, J., and Brodie, B. B., Ann. N. Y. Acad. Sci., 96, 279 (1962).
Hucker, H. B., Pharmacologist, 4, 171 (1962).
Brodie, B. B., Bickel, M. H., and Sulser, F., Med. exp., 5, 454 (1961).
Rathbun, R. C., and Slater, J. H., Psychopharmacologia, 4, 114 (1963).
Hippins, H., Canad. Psychiat. Assoc. J., 4, S, 182 (1959).
Bickel, O. H., Sulser, F., and Brodie, B. B., Life Sci., 4, 247 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
VÍTEK, V., MOSINGER, B. & KUJALOVÁ, V. In vitro Interference of Antidepressants with Lipolytic Action of Adrenaline on Adipose Tissue. Nature 205, 90–91 (1965). https://doi.org/10.1038/205090b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/205090b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.