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Sialic Acid-deficient α1-Acid Glycoprotein produced in Certain Pathological States

Nature volume 204, pages 75–76 (1964)Cite this article

Abstract

THE seromucoid fraction, one of the ‘acute phase react ants’, has been shown by many investigators to be increased significantly in the blood in a large number of unrelated disease states. This protein fraction1 is known to contain as major component α1-acid glyco-protein2 or orosomucoid3 and several minor components including haptoglobin, 3S α1-glycoprotein and Zn- and Ba-α2-glycoproteins4,5. The question has now been investigated whether α1-acid glycoprotein derived from pathological plasma is identical to or different from that prepared from normal blood.

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References

  1. Schultze, H. E., Heide, K., and Haupt, H., Clin. Chim. Acta, 7, 854 (1962).

    Article  CAS  Google Scholar 

  2. Schmid, K., J. Amer. Chem. Soc., 75, 60 (1953).

    Article  CAS  Google Scholar 

  3. Weimer, H. E., Winzler, R. J., and Mehl, J. W., J. Biol. Chem., 185, 561 (1950).

    CAS  PubMed  Google Scholar 

  4. Schmid, K., and Bürgi, W., Biochim. Biophys. Acta, 47, 440 (1961).

    Article  CAS  Google Scholar 

  5. Bürgi, W., and Schmid, K., J. Biol. Chem., 236 1066 (1961).

    PubMed  Google Scholar 

  6. Lever, W. L., Gurd, F. R. N., Uroma, E., Brown, R. K., Barnes, B. A., Schmid, K., and Schultze, E. L., J. Clin. Invest., 30, 991 (1951).

    Article  Google Scholar 

  7. Schmid, K., MacNair, M. B., and Bürgi, A. F., J. Biol. Chem., 230, 853 (1958).

    CAS  PubMed  Google Scholar 

  8. Warren, L., J. Biol. Chem., 234, 1971 (1959).

    CAS  Google Scholar 

  9. Winzler, R. J., in Methods in Biochemical Analysis, edit. by Glick, D., 2, 279 (Interscience Publishing Company, New York, 1955).

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, Boston University School of Medicine,

    K. SCHMID, J. F. BURKE, MONIQUE DEBRAY-SACHS & K. TOKITA

  2. Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Mass.

    K. SCHMID, J. F. BURKE, MONIQUE DEBRAY-SACHS & K. TOKITA

Authors
  1. K. SCHMID
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  2. J. F. BURKE
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  3. MONIQUE DEBRAY-SACHS
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  4. K. TOKITA
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SCHMID, K., BURKE, J., DEBRAY-SACHS, M. et al. Sialic Acid-deficient α1-Acid Glycoprotein produced in Certain Pathological States. Nature 204, 75–76 (1964). https://doi.org/10.1038/204075a0

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