Abstract
PREVIOUS investigations1 demonstrated that a synthetic polypeptide containing D-glutamic acid, D-lysine and D-tyrosine is capable of eliciting an antibody response in rabbits: poly D-Glu55D-Lys39D-Tyr6* elicited an average of 26 ± 33 µg Ab N/ml. in 13/17 animals, whereas its L-counterpart, poly Glu56Lys38Tyr6, elicited 91 ± 52 µg Ab N/ml. in 38/38 animals. In view of this finding, we undertook to determine whether the D-amino-acid polypeptide was capable of being degraded in vivo. In addition, we planned to explore the metabolism of another L-amino-acid counterpart of the D-polymer, poly Glu58Lys36Tyr6 (No. 2), both as a control for the behaviour of the D-polymer and also to examine further some of the anomalous findings of our previous metabolic study on synthetic polypeptides2.
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GILL, T., PAPERMASTER, D. & MOWBRAY, J. Metabolism of Isomeric Synthetic Polypeptides. Nature 203, 644–645 (1964). https://doi.org/10.1038/203644a0
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DOI: https://doi.org/10.1038/203644a0
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