Abstract
THE effects of a lethal injection of cobra venom, rattlesnake venom, or E. coli endotoxin on the cardiovascular system of the dog and monkey have been described previously in detail. The administration of endotoxin results in hypotension, acidosis, hæmolysis, and renal failure1–4. A similar effect is seen following the administration of snake venom5,6. No reports, however, describe the effects of these compounds on the central nervous system. The purpose of work recorded here, therefore, was to determine if a change in cortical electrical activity follows a lethal injection of these toxins.
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References
Gilbert, R. P., Physiol. Rev., 40, 245 (1960).
Hinshaw, L. B., Spink, W. W., Vick, J. A., Mallett, E., and Finstad, J., Amer. J. Physiol., 201, 144 (1961).
Spink, W. W., Ann. Intern. Med., 57, 538 (1962).
MacLean, L. D., Surg. Gynec. Obstet., 115, 307 (1962).
Russell, F. E., Buess, F. W., and Strassberg, J., Toxicon, 1, 5 (1962).
Sarkar, B. B., Mitra, S. R., and Ghosh, B. N., Indian J. Med. Res., 30, 453 (1942).
Vick, J. A., Fed. Proc., 23, 539 (1964).
Gautrelet, J., Halpern, N., and Cortiggiani, E., Arch. Intern. Physiol., 38, 293 (1934).
Chang, C. C., and Lee, C. Y., Archives Inter. de Pharmaco. et de Therapie, 144, 241 (1963).
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VICK, J., CIUCHTA, H. & POLLEY, E. Effect of Snake Venom and Endotoxin on Cortical Electrical Activity. Nature 203, 1387–1388 (1964). https://doi.org/10.1038/2031387b0
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DOI: https://doi.org/10.1038/2031387b0
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