Abstract
BESIDES giving rise to liver tumours1, ethionine administration causes inhibition of protein synthesis1,2 and also, in common with actinomycin D and puromycin, can reduce the extra synthesis of certain enzymes occurring in liver under the influence of ‘inducing’ agents3. Actinomycin D is known to suppress the synthesis of ribonucleic acid (RNA) possibly including ‘messenger’ RNA, in vivo or in vitro, and puromycin likewise suppresses RNA synthesis at least when administered to partially hepatectomized rats4. A fall in the incorporation of labelled precursors into RNA has been briefly reported to occur in liver after acute treatment with ethionine in large dosage2,5, in accordance with the inhibiting effect on protein synthesis. Surprisingly, however, we have now encountered a converse effect on RNA synthesis in rats fed ethionine.
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References
Farber, E., Adv. Cancer Res., 7, 383 (1963).
Farber, E., Shull, K. H., Villa-Trevino, S., Lombardi, B., and Thomas, M., Nature, 203, 34 (1964).
Weber, G., et al., in Adv. Enzyme Regulation, 1, 1 (1963).
Gottlieb, L. I., Fausto, N., and Van Lancker, J. L., J. Biol. Chem., 239, 555 (1964).
Villa-Trevino, S., Shull, K. H., and Farber, E., Fed. Proc., 22, 237 (1963). Natori, Y., and Tarver, H., Abstracts of 6th Internat. Congr. Biochem., 77 (1964).
Weiss, S. B., Proc. U.S. Nat. Acad. Sci., 46, 1020 (1960).
Chauveau, J., Moulé, Y., and Rouiller, C., Exp. Cell Res., 11, 317 (1956). Chauveau, J. (personal communication, to M. K. T).
Goldberg, I. H., Biochim. Biophys. Acta, 51, 201 (1961).
Shull, K. H., Villa-Trevino, S., and Oler, A., Abstracts of 6th Internat. Congr. Biochem., 86 (1964).
Hawtrey, A. O., and Nourse, L. D., Biochim. Biophys. Acta, 80, 530 (1964).
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TURNER, M., REID, E. An Anomalous Effect of Ethionine on Ribonucleic Acid Synthesis. Nature 203, 1174–1175 (1964). https://doi.org/10.1038/2031174a0
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DOI: https://doi.org/10.1038/2031174a0
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