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Dissociation of Bacterial 0 Antigen from Rabbit Erythrocytes

Nature volume 203, pages 1081–1082 (1964)Cite this article

Abstract

IT has been shown1 that rabbit erythrocytes modified in vitro with 0 antigens (endotoxins) of Salmonella typhi or Escherichia coli are rapidly destroyed when injected into rabbits previously immunized with the corresponding bacterial antigen. In contrast, modified erythrocytes administered to non-immune rabbits have a normal life span despite the fact that specific antibody appears within six days after injection of the modified red blood cells. Thus, it becomes important to ascertain whether bacterial antigens attached to erythrocytes in vitro remain bound to the red blood cells for their entire period of survival after they are re-introduced into the animal's circulation.

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References

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Author notes

  1. CLARE N. SHUMWAY

    Present address: Department of Pediatrics, Medical College of Virginia, Richmond, Virginia, U.S.A.

Authors and Affiliations

  1. Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York

    CLARE N. SHUMWAY

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  1. CLARE N. SHUMWAY
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SHUMWAY, C. Dissociation of Bacterial 0 Antigen from Rabbit Erythrocytes. Nature 203, 1081–1082 (1964). https://doi.org/10.1038/2031081a0

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