Abstract
THE belief that hypercholesterolæmia plays a contributory part in the ætiology of atherosclerosis has stimulated the search in many laboratories for compounds which would lower serum cholesterol by inhibition of endogenous cholesterol synthesis. Recent work in our laboratories has led to the synthesis of trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride (mol. wt. 464.3)—‘AY–9944’, and the subsequent demonstration that this compound represents a new class of inhibitors of the biosynthesis of cholesterol1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dvornik, D., Kraml, M., Dubuc, J., Givner, M., and Gaudry, R., J. Amer. Chem. Soc., 85, 3309 (1963).
Tavormina, P. A., Gibbs, M. H., and Huff, J. W., J. Amer. Chem. Soc., 78, 4498 (1956).
Bucher, N. L. R., and McGarrahan, K., J. Biol. Chem., 221, 1 (1956).
Zlatkis, A., Zak, B., and Boyle, A. J., J. Lab. Clin. Med., 41, 486 (1953).
Avigan, J., Steinberg, D., Vroman, H. E., Thompson, M. J., and Mosettig, E., J. Biol. Chem., 235, 3123 (1960).
Sachs, B. A., and Wolfman, L., Metabolism, 12, 608 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CHAPPEL, C., DUBUC, J., DVORNIK, D. et al. An Inhibitor of Cholesterol Biosynthesis. Nature 201, 497–498 (1964). https://doi.org/10.1038/201497a0
Issue Date:
DOI: https://doi.org/10.1038/201497a0
This article is cited by
-
Effect of inhibitors of sterol biosynthesis on growth and sexuality of pythium and zygorhynchus
Mycopathologia (1976)
-
Effects of triparanol and AY‐9944 upon sterol biosynthesis inChlorella
Lipids (1974)
-
Inhibition of sterol biosynthesis in chlorella ellipsoidea by AY‐99441
Lipids (1972)
-
An Inhibitor of Adrenal Steroid 11β-Hydroxylase
Nature (1964)
-
Inhibition of drug metabolism in the mouse by a hypocholesterolemic agent, AY-9944
Experientia (1964)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
