Abstract
DURING starvation, glycogenolysis is associated with the release of the enzymes phosphorylase and glycogen synthetase from insoluble granules into the cytoplasm. This event is accompanied by a decrease in the activity of glycogen synthetase and a transient increase in phosphorylase activity. The phenomena can be prevented by the prior administration of the glucocorticoid, cortisol. Moreover, once the alterations have occurred, they can be reversed by glycogenesis produced by either cortisol injection or glucose feeding, DOCA was ineffective.
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SIE, HG., HABLANIAN, A. & FISHMAN, W. Solubilization of Mouse Liver Glycogen Synthetase and Phosphorylase during Starvation Glycogenolysis and its Reversal by Cortisol. Nature 201, 393–394 (1964). https://doi.org/10.1038/201393a0
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DOI: https://doi.org/10.1038/201393a0
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