Abstract
IN previous communications1,2, a potent clotting factor other than thrombin was reported to be present in aqueous fibrin extracts. It was shown to be a glucuronide and to contain calcium, probably combined as calcium glucuronidate. The rest of the molecule remained unidentified. A suggestion was made that it might be related to vitamin D2; however, extracts proved to be ineffective in curing rickets in rats raised on a diet free of vitamin D. Attention was then directed to vitamin K, since vitamins K1 and K3 (menadione) were found to be excreted in urine partly as diglucuronides of menadione3. Ultra-violet absorption of diluted clotting factor preparations gave a spectrum almost identical with that of 1,4-naphthohydroquinone diacetate, the only compound available for comparison, with a maximum at 280 mµ for the former and 284 mµ for the latter and a minimum at 250 mµ for both.
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References
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KOPPER, P. Direct Role of Vitamin K Derivative in Fibrin Formation. Nature 201, 1335–1336 (1964). https://doi.org/10.1038/2011335a0
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DOI: https://doi.org/10.1038/2011335a0
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