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Re-utilization of Thymidine during Death of a Cell

Nature volume 201, pages 93–94 (1964)Cite this article

Abstract

THE death of cells offers a situation by which salvage pathways can be studied. Thus, following large doses of X-irradiation, death of a murine ascites lymphoma cell occurs by a rapid intermitotic mechanism1. The deoxyribonucleic acid (DNA) of these cells was labelled with tritiated thymidine, the cells killed by X-irradiation, and injected intravenously into recipient mice with growing ascites tumours. Label appeared in the DNA of the tumour and bone marrow cells of the recipient mice, with all µthe radioactivity being present as thymine. This indicates a salvage and conservation mechanism for these molecules.

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  1. Department of Radiology, Stanford University School of Medicine, Palo Alto, California

    YOSH MARUYAMA

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  1. YOSH MARUYAMA
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MARUYAMA, Y. Re-utilization of Thymidine during Death of a Cell. Nature 201, 93–94 (1964). https://doi.org/10.1038/201093a0

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