Abstract
PROMPTED by the striking difference in lactic dehydrogenase activity observed by Woodliff1 in sensitive L1210 leukæmic cells compared with those resistant to amethopterin and 6-mercaptopurine we have examined lactic dehydrogenase-levels in sensitive L1210Z and a strain (L1210C59) resistant to both amethopterin and 6-mercaptopurine and partially resistant to cytoxan.
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Woodliff, H. J., Nature, 191, 1313 (1961).
Goldin, A., Venditti, J. M., Humphreys, S. R., and Mantel, N., J. National Cancer Inst., 21, 495 (1958).
Layne, E., Methods in Enzymology, 3, 451 (Academic Press, New York, 1957).
Kaplan, N. O., and Cahn, R. D., Proc. U.S. Nat. Acad. Sci., 48, 2123 (1962).
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KISLIUK, R., ZEL, G., WALTER, H. et al. Lactic Dehydrogenase in L1210 Cells. Nature 200, 903 (1963). https://doi.org/10.1038/200903a0
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DOI: https://doi.org/10.1038/200903a0
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