Abstract
STRAINS of bacteria can be divided into two classes depending on their ability to effect dark repair of ultraviolet-induced damage to phage DNA1. Those strains which manifest this ability are hcr+ (host-cell reactivation positive) and those which show a reduced ability are hcr− (ref. 2). Since post-irradiation exposure of bacteria to basic dyes reduces the ability to repair damage to their own DNA, presumably by hindering replication3, a similar effect of these dyes on irradiated phage DNA might be expected. Under these conditions, hcr+ strains would then resemble hcr− strains. This possibility has been confirmed.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Garen, A., and Zinder, N. D., Virology, 1, 347 (1955).
Harm, W., Z. Vererb., 94, 67 (1963).
Witkin, E. M., J. Cell Comp. Physiol., 58, Supp. 1, 135 (1961).
Hill, R. F., and Simson, E., J. Gen. Microbiol., 24, 1 (1961).
Ellison, S. A., Feiner, R. R., and Hill, R. F., Virology, 11, 294 (1960).
Hill, R. F., and Feiner, R. R., Rad. Res., 19, No. 1, 234 (1963).
Hill, R. F., and Rossi, H. H., Science, 116, 424 (1952).
Yamamoto, N., J. Bact., 75, 443 (1958)
Dulbecco, R., J. Bact., 59, 329 (1950).
Foster, R., J. Bact., 56, 795 (1948).
Sauerbier, W., Virology, 17, 164 (1962).
Bellin, J. S., and Oster, G., Biochim. Biophys. Acta, 42, 533 (1960).
Fraser, D. K., Virology, 3, 527 (1957).
Sinsheimer, R. L., The Nucleic Acids, edit. by Chargaff, E., and Davidson. J. N., 3, 187 (Academic Press, 1960).
Sauerbier, W., Virology, 16, 398 (1962).
Howard-Flanders, P., and Theriot, L., Genetics, 47, 1219 (1962).
Lyman, J. T., Haynes, R. H., and Tobias, C. A., Rad. Res., 19, 237 (1963).
Haynes, R. H., and Inch, W. R. (in preparation).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FEINER, R., HILL, R. Effect of Basic Dyes on Host-cell Reactivation of Ultra-violet-irradiated Phage. Nature 200, 291–293 (1963). https://doi.org/10.1038/200291a0
Issue Date:
DOI: https://doi.org/10.1038/200291a0
This article is cited by
-
Inducible reactivation of UV-irradiated cholera phage e5 in Vibrio cholerae MAK757
Molecular and General Genetics MGG (1987)
-
Evidence for differing modes of interaction of acriflavine with ultraviolet-induced lesions in an Hcr+ bacterial strain
Molecular and General Genetics MGG (1973)
-
Evidence for a Further Dark Repair Process in Bacteria
Nature New Biology (1972)
-
Mitotic non-conformity in Aspergillus nidulans: the effects of caffeine
Molecular and General Genetics MGG (1972)
-
Different photodynamic action of proflavine and methylene blue on bacteriophage
Molecular and General Genetics MGG (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
