Abstract
QUITE a few physical and chemical inducers of chromosomal aberrations have been tested for interaction of chromatid breaks induced by different agents, the product of interaction being chromatid translocations (exchanges). On the basis of the breakage-reunion hypothesis presence or absence of interaction may be expected to give some hints on the bonds broken by the treatments being identical (full interaction) or not (no interaction, additive effect), provided time (different stages of maximal sensitivity against the agents) and space factors (different distribution of aberrations within and between chromosomes) can be ruled out as influencing the experimental results.
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MICHAELIS, A., RIEGER, R. Interaction of Chromatid Breaks induced by Three Different Radiomimetic Compounds. Nature 199, 1014–1015 (1963). https://doi.org/10.1038/1991014a0
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DOI: https://doi.org/10.1038/1991014a0
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