Abstract
PYRIMIDINES halogenated in position 5 have been shown to sensitize bacteria1, bacteriophages2 and mammalian cells3 to ultra-violet irradiation. In all these cases substitution of thymine, a specific constituent of deoxy-ribonucleic acid (DNA), by its halogenated analogues is implicated as the primary cause of increased sensitivity. This, together with the fact that one of the analogues, 5-bromouracil, is a known mutagenic agent in bacteria4 and bacteriophages5, strongly suggests that genetic material, that is, DNA, is the primary target of irradiation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kaplan, H. S., Smith, K. C., and Tomlin, P. A., Rad. Res., 16, 98 (1962).
Stahl, F. W., Graseman, J. M., Oku, L., Fox, E., and Laird, C., Virology, 13, 98 (1961).
Djordjević, B., and Szybalski, W., J. Exp. Med., 112, 509 (1960).
Rudner, R., and Balbinder, E., Nature, 186, 180 (1960).
Litman, R. M., and Pardee, A. B., Nature, 178, 529 (1956).
Zamenhof, S., Reiner, B., De Giovanni, R., and Rich, K., J. Biol. Chem., 219, 165 (1956).
Bagshaw, M. A., Amer. J. Roentgenol. Radium Therapy Nuclear Med., 85, 822 (1961).
Ben-Ishai, R., Goldin, H., and Oppenheim, B., Biochim. Biophys. Acta, 55, 748 (1962).
Heidelberger, C., Griesbach, L., Duschinsky, R., Schnitzer, R. J., Pleven, E., and Scheiner, J., Nature, 179, 663 (1957).
Horowitz, J., and Chargaff, E., Nature, 184, 1213 (1959).
Gordon, M. P., and Staehelin, M., Biochim. Biophys. Acta, 36, 351 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BEĆAREVIĆ, A., DJORDJEVIĆ, B. & ŠUTIĆ, D. Effect of Ultra-violet Light on Tobacco Mosaic Virus containing 5-Fluorouracil. Nature 198, 612–613 (1963). https://doi.org/10.1038/198612a0
Issue Date:
DOI: https://doi.org/10.1038/198612a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
