Abstract
RECENT investigations1–3 have revealed the natural existence, in certain guinea pigs, of a state of delayed iso-hypersensitivity toward a heritable factor present in the serum of other normal guinea pigs. The observation that this serum factor, which was first detected in animals of Rockefeller Institute stock, is present also in guinea pigs of the more inbred (nevertheless also heterozygous) Hartley strain but not in animals of the homozygous Wright strains II and XIII (ref. 2) suggested a means for investigating the mechanism of its heritability. Results presented here, obtained by interbreeding strain XIII and Hartley animals, indicate that the presence of serum factor in guinea is pigs controlled by an autosomal dominant gene.
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References
Battisto, J. R., Nature, 187, 69 (1960).
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Battisto, J. R., Proc. Soc. Exp. Biol. and Med., 106, 725 (1961).
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BATTISTO, J. Genetic Control of a Guinea Pig Serum Factor toward which Natural Delayed Iso-hypersensitivity occurs. Nature 198, 598–599 (1963). https://doi.org/10.1038/198598b0
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DOI: https://doi.org/10.1038/198598b0
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