Abstract
PREVIOUS work has indicated that the initial increase in vascular permeability occurring in the pleura after intrapleural injection of turpentine is due to local release of histamine, the vascular changes being afterwards maintained by other mechanisms1. A similar sequence of events appears to occur after thermal and irradiation injury2–4. The evidence on which these conclusions are based consists of pharmacological assays of exudates and tissues, the effect of small doses of antihistamine drugs and the effect of depletion of bodily stores of histamine.
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SPECTOR, W., WILLOUGHBY, D. & FREARS, J. Sulphydryl Groups and Histamine Release in vivo. Nature 198, 595–596 (1963). https://doi.org/10.1038/198595a0
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DOI: https://doi.org/10.1038/198595a0
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