Abstract
IN man copper can be mobilized from the body by the intramuscular or intravenous administration of BAL (dimercaptopropanol)1,2 or by the oral administration of penicillamine (dimethyl cysteine)3. Further, it has been shown that penicillamine brings about a fall in the plasma level of copper which later rapidly returns to normal4; the plasma copper presumably being made good from tissue stores. There is no direct evidence as to the effect of either of these chelating agents on the copper–protein bonds in tissues. We have investigated the ability of BAL and penicillamine to render liver copper available for nitration through a semipermeable membrane.
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FREYER, S., WALSHE, J. Effect of Chelating Agents on the Copper–Protein Bond in Liver. Nature 198, 189 (1963). https://doi.org/10.1038/198189a0
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DOI: https://doi.org/10.1038/198189a0
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