Antagonistic Action of Urokinase to Brady-kinin- and Plasminogen-induced Capillary Permeability

Abstract

PREVIOUSLY we reported observations on the inhibitory action of fibrinolysin and streptokinase, as well as of other proteolytic enzymes, on capillary permeability induced by different mediators in rats and guinea pigs^1,2. These findings led to investigations on urokinase and plasmino-gen. We used the blueing reaction, a semi-quantitative test, in these animals and found in control studies that urokinase did not induce capillary permeability. The failure of plasmin to induce capillary permeability was already published by Bhoola, Calle and Schachter³, and we could confirm this both with streptokinase and chloroform activated fibrinolysin (plasmin). We have now found that urokinase behaves in a similar manner. In control experiments using buffered plasminogen, we found that it produced the opposite effect to that obtained with fibrinolysin, streptokinase and urokinase, respectively.