Abstract
THE action of cytotoxic drugs in experimental allergic encephalomyelitis is of interest in the examination of the mechanism of this disease in animals and may have therapeutic implications for auto-immune disease in man. Hoyer et al.1 have shown that 6-mercaptopurine can suppress experimental allergic encephalomyelitis in rabbits and guinea pigs, but Field2 has reported negative findings in the latter species.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hoyer, L. W., Good, R. A., and Condie, R. M., J. Exp. Med., 116, 311 (1962).
Field, E. J., Proc. Roy. Soc. Med., 54, 15 (1961).
Freidman, R. M., Buckler, C. E., and Baron, S., J. Exp. Med., 114, 173 (1961).
Maguire, H. C., and Maibach, H. I., J. Allergy, 32, 406 (1961).
Page, A. R., Condie, R. M., and Good, R. A., Amer. J. Path., 40, 519 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CALNE, D., LEIBOWITZ, S. Suppression of Experimental Allergic Encephalomyelitis by Cytotoxic Drugs. Nature 197, 1309–1310 (1963). https://doi.org/10.1038/1971309b0
Issue Date:
DOI: https://doi.org/10.1038/1971309b0
This article is cited by
-
Role of Immunosuppressive Therapy for the Treatment of Multiple Sclerosis
Neurotherapeutics (2013)
-
Cyclophosphamide inhibition of insulin antibody production, insulin resistance and experimental immunodiabetes
Acta Diabetologica Latina (1972)
-
Wirkung eines heterologen Antilymphocytenserums auf die experimentelle allergische Encephalomyelitis
Klinische Wochenschrift (1969)
-
Die Depression der primären Immunitätsreaktion durch 6-Mercaptopurin und Cyclophosphamid bei verschiedenen Tierarten
Zeitschrift für Die Gesamte Experimentelle Medizin einschließlich experimentelle Chirurgie (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
