Abstract
MOST investigators who preserve sera for future analysis take it for granted that the serum proteins are stable at temperatures around −20° C. Some evidence supports this assumption: the titres of certain antibodies or of rheumatoid factor, for example, remain unaltered after even several years in a deep freeze. This communication shows that most human sera, from both healthy and sick people, contain an α-2 globulin which loses its antigenic (precipitin) characteristics after prolonged storage at −20° C.
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FESSEL, W. Loss of Immunological Reactivity of an Alpha-2 Globulin after Prolonged Freezing of Serum. Nature 197, 1307 (1963). https://doi.org/10.1038/1971307a0
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DOI: https://doi.org/10.1038/1971307a0
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