Abstract
KALLIKREIN, discovered by Frey in 19251, was observed to be a hypotensive agent. Later work by many investigators has led to the present hypothesis that kallikrein is an enzyme, formed from a precursor kallikreininoken, which acts on protein substrates to liberate the biologically active polypeptides, substance P, kallidin II, and bradykinin. It is these substances which manifest the hypotensive activity2,3. Because trypsin possesses the same ability to release active polypeptides, it becomes important for future investigations to differentiate clearly the two enzymes, trypsin and kallikrein.
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References
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CHAMBERS, D., BOSSER, C., GREEP, J. et al. Enzymatic Investigations of Partially Purified Hog Kallikrein. Nature 197, 1300–1301 (1963). https://doi.org/10.1038/1971300a0
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DOI: https://doi.org/10.1038/1971300a0
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