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Composition of Normal and Pathological Cutaneous Elastin

Nature volume 197, pages 1108–1109 (1963)Cite this article

Abstract

ELASTIN, a fibrous protein invariably associated with collagen1,2, has been quantitatively measured in a variety of mammalian tissues3,4. The amino-acid composition of elastin prepared from various animal sources including aorta5, lung6 and ligamentum nuchæ7 has been reported and the elastin content of human dermis has been determined8,9. The purpose of this work was to determine tho amino-acid composition of human dermal elastin and compare it with that of the elastin-like proteins found in increased amounts in chronically sun-damaged skin (actinic elastosis) and pseudoxanthoma elasticum8.

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References

  1. Hall, D. A., Keech, M. K., Reid, R., Tunbridge, R. E., and Wood, H. J., J. Gerontol., 10, 388 (1955).

    Article  CAS  Google Scholar 

  2. Lansing, A. I., in The Arterial Watt, edit. by Lansing, A. I., 186 (Williams and Wilkins, Baltimore, 1959).

    Google Scholar 

  3. Lowry, O. H., Gilligan, D. R., and Katersky, E. H., J. Biol. Chem., 139, 795 (1941).

    CAS  Google Scholar 

  4. Neuman, R. E., and Logan, M. A., J. Biol. Chem., 186, 549 (1950).

    CAS  PubMed  Google Scholar 

  5. Lansing, A. I., Roberts, E., Ramasarma, G. B., Rosenthal, T. B., and Alex, M., Proc. Soc. Exp. Biol. Med., 76, 714 (1951).

    Article  CAS  Google Scholar 

  6. Hospelhorn, V. D., and Fitzpatrick, M. J., Biochem. Biophys. Res. Comm., 6, 191 (1961).

    Article  CAS  Google Scholar 

  7. Partridge, S. M., and Davis, H. F., Biochem. J., 61, 21 (1955).

    Article  CAS  Google Scholar 

  8. Smith, jun., J. G., Davidson, E. A., and Clark, R. D., Nature, 195, 716 (1962).

    Article  ADS  Google Scholar 

  9. Weinstein, G. D., and Boucek, R. J., J. Invest. Derm., 35, 227 (1960).

    Article  CAS  Google Scholar 

  10. Loewi, G., Glynn, L. E., and Dorling, J. L., J. Path. Bact., 80, 1 (1960).

    Article  CAS  Google Scholar 

  11. Smith, jun., J. G., Davidson, E. A., Sams, jun., W. M., and Clark, R. D., J. Invest. Derm., 39, 347 (1962).

    Article  CAS  Google Scholar 

  12. Smith, jun., J. G., Sams, jun., W. M., Davidson, E. A., and Clark, R. D., Arch. Derm., 86, 741 (1962).

    Article  Google Scholar 

  13. Neuman, R. E., and Logan, M. A., J. Biol. Chem., 184, 299 (1950).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Dermatology, Department of Medicine, the Department of Biochemistry and the Center for the Study of Aging, Duke University Medical Center, Durham, North Carolina

    J. GRAHAM SMITH JUN., EUGENE A. DAVIDSON & ROBERT L. HILL

Authors
  1. J. GRAHAM SMITH JUN.
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  2. EUGENE A. DAVIDSON
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  3. ROBERT L. HILL
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SMITH, J., DAVIDSON, E. & HILL, R. Composition of Normal and Pathological Cutaneous Elastin. Nature 197, 1108–1109 (1963). https://doi.org/10.1038/1971108b0

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