Abstract
WHILE seeking to demonstrate the organ specificity of cardiac tissue1,2, an attempt was made to produce a specific antiserum in the rats using the phenomena of immunotolerance3,4. New-born rats received 18 daily intraperitoneal injections of homogenates of pooled organs (lung, liver, spleen, kidney and serum) of bovines, rabbits or guinea pigs during 3 weeks, followed by 3 weekly injections, a total of 220–250 mg protein being given to each rat. Other groups were given homogenate of heart or of heart and organ-pool and an untreated control group was included in each series.
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References
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DAVIES, A., GERY, I. Immunotolerance to Heterologous Heart in the Rat. Nature 196, 184–185 (1962). https://doi.org/10.1038/196184a0
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DOI: https://doi.org/10.1038/196184a0
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