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A Pool Size Problem associated with the Use of Tritiated Thymidine

Nature volume 194, pages 886–887 (1962)Cite this article

Abstract

HELL et al.1 have directed the attention of research workers to the fact that errors may result from the use of high specific activity radioactive compounds when the intracellular concentration of the corresponding metabolites is very low. In particular they mentioned tritiated thymidine and showed that the apparent effects of irradiation on the incorporation of this compound by Ehrlich ascites cells depended on whether tritiated thymidine of high or low specific activity was used. They ascribed this effect to differences in pool size in the irradiated cells.

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Author notes

  1. P. P. DENDY: Holder of Scholarship from the Medical Research Council, Great Britain.

Authors and Affiliations

  1. Department of Biochemistry, Cambridge

    ALISON NEWTON

  2. Department of Radiotherapeutics, Cambridge

    P. P. DENDY

  3. Department of Radiotherapeutics, Cambridge

    C. L. SMITH

  4. Medical Research Council Unit for Experimental Virus Research, Glasgow

    P. WILDY

Authors
  1. ALISON NEWTON
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  2. P. P. DENDY
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  3. C. L. SMITH
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  4. P. WILDY
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NEWTON, A., DENDY, P., SMITH, C. et al. A Pool Size Problem associated with the Use of Tritiated Thymidine. Nature 194, 886–887 (1962). https://doi.org/10.1038/194886a0

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