This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bertino, J. R., Gabrio, B. W., and Huennekens, F. M., Biochem. Biophys. Res. Comm., 3, 461 (1960).
Huennekens, F. M., and Osborn, M. J., Adv. in Enzymol., 21, 369 (1959). Rabinowitz, J. C., in The Enzymes, edit. by Boyer, P. D., Lardy, H., and Myrback, K., 2, 85 (Academic Press, New York, 1960).
Humphreys, G. K., and Greenberg, D. M., Arch. Biochem. Biophys., 78, 275 (1958). McDougall, B. M., and Blakley, R. L., Biochim. Biophys. Acta, 39, 176 (1960). Friedkin, M., Federation Proc., 18, 230 (1959).
Nichol, C. A., and Welch, A. D., Proc. Soc. Exp. Biol. Med., 74, 403 (1950). Futterman, S., and Silverman, M., J. Biol. Chem., 224, 31 (1957). Futterman, S., ibid., 228, 1031 (1957). Osborn, M. J., Freeman, M. I., and Huennekens, F. M., Proc. Soc. Exp. Biol. Med., 97, 429 (1958). Zakrzewski, S. F., and Nichol, C. A., Biochim. Biophys. Acta, 27, 425 (1958). Peters, J., and Greenberg, D. M., J. Amer. Chem. Soc., 80, 6679 (1958).
Bertino, J. R., Alenty, A., Gabrio, B. W., and Huennekens, F. M., Clin. Res., 8, 206 (1960).
Bertino, J. R., Huennekens, F. M., and Gabrio, B. W., Clin. Res., 9, 103 (1961).
Fischer, G. A., Proc. Amer. Assoc. Cancer Res., 3, 111 (1960).
Werkheiser, W. C., Proc. Amer. Assoc. Cancer Res., 3, 72 (1959).
Misra, D. K., Humphreys, S. R., Friedkin, M., Goldin, A., and Crawford, E. J., Nature, 189, 39 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BERTINO, J., DONOHUE, D., GABRIO, B. et al. Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin. Nature 193, 140–142 (1962). https://doi.org/10.1038/193140a0
Issue Date:
DOI: https://doi.org/10.1038/193140a0
This article is cited by
-
Selection for methotrexate resistance in mammalian cells bearing a Drosophila dihydrofolate reductase transgene
Cell Biology and Toxicology (2010)
-
Methotrexate interaction with a lipid membrane model of DPPC
Journal of Thermal Analysis (1995)
-
Inhibition of neutrophil chemotaxis in methotrexate-treated rheumatoid arthritis patients
Rheumatology International (1988)
-
Wirkung und Verteilung von Methotrexat im menschlichen Organismus bei der Leukämiebehandlung
Klinische Wochenschrift (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.