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Demethylation in the Metabolism of (—)-Nicotine in vivo

Nature volume 190, pages 910–911 (1961)Cite this article

Abstract

THE physiological disposition of nicotine randomly labelled with carbon-14 has been subjected to investigation by many authors1–3. After intravenous administration to mice1 and to dogs2 analyses of the expired air showed no radioactive carbon dioxide. In an extension of this work, in which degradation of nicotine was investigated, the methylamine fraction of dog urine was examined for radioactivity and found3 to contain none.

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References

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Author information

Author notes

  1. EINOSUKE WADA

    Present address: Central Research Laboratory, Japan Monopoly Corporation, Tokyo

  2. EINOSUKE WADA: American Tobacco Company Research Fellow.

  3. EDWARD R. BOWMAN: Public Health Research Fellow of the National Heart Institute.

Authors and Affiliations

  1. Department of Pharmacology, Medical College of Virginia, Richmond, Virginia

    HERBERT McKENNIS JUN., EINOSUKE WADA, EDWARD R. BOWMAN & LENNOX B. TURNBULL

Authors
  1. HERBERT McKENNIS JUN.
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  2. EINOSUKE WADA
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  3. EDWARD R. BOWMAN
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  4. LENNOX B. TURNBULL
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McKENNIS, H., WADA, E., BOWMAN, E. et al. Demethylation in the Metabolism of (—)-Nicotine in vivo . Nature 190, 910–911 (1961). https://doi.org/10.1038/190910a0

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  • DOI: https://doi.org/10.1038/190910a0

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