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Hormonal Induction of Alkaline Phosphatase in Human Cells in Tissue Culture

Nature volume 190, pages 85–87 (1961)Cite this article

Abstract

DURING an investigation of differences between established lines of human cells in culture, the alkaline phosphatase content was found to vary from high activity in certain epithelial lines to trace or no detectable activity in other epithelial lines. In a series of six HeLa lines the variation in alkaline phosphatase was as great as among cell lineo derived from other tissues and from different species. Among the six lines of uncloned HeLa cells four showed marked ‘constitutive’ alkaline phosphatase activity and two showed trace or no activity (Table 1).

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References

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Author notes

  1. COLIN M. MACLEOD

    Present address: Department of Medicine, New York University, New York

  2. BODY P. COX: Public Health Postdoctoral Research Fellow CF 10,017.

Authors and Affiliations

  1. Department of Research Medicine, University of Pennsylvania School of Medicine, Philadelphia, 4, Pennsylvania

    BODY P. COX & COLIN M. MACLEOD

Authors
  1. BODY P. COX
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  2. COLIN M. MACLEOD
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COX, B., MACLEOD, C. Hormonal Induction of Alkaline Phosphatase in Human Cells in Tissue Culture. Nature 190, 85–87 (1961). https://doi.org/10.1038/190085a0

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