Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

The Evolution of Overdominance: Natural Selection and Heterozygote Advantage

Nature volume 190, pages 7–12 (1961)Cite this article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Dobzhansky, Th., Cold Spring Harbor Symp. Quantitative Biol., 20, 1 (1955).

    Article  CAS  Google Scholar 

  2. Haldane, J. B. S., The Biochemistry of Genetics (Allen and Unwin, 1954).

    Google Scholar 

  3. Lerner, I. M., Genetic Homeostasis (John Wiley, 1954).

    Google Scholar 

  4. Fisher, R. A., The Theory of Inbreeding (Oliver and Boyd, 1949).

    MATH  Google Scholar 

  5. Mather, K., Proc. Roy. Soc., B, 144, 143 (1955).

    Article  ADS  CAS  Google Scholar 

  6. Crow, J. F., Genetics, 33, 447 (1948).

    Google Scholar 

  7. Fisher, R. A., The Genetical Theory of Natural Selection (Oxford University Press, 1930).

    Book  Google Scholar 

  8. Haldane, J. B. S., Amer. Nat., 71, 337 (1937).

    Article  Google Scholar 

  9. Schuler, J. F., and Sprague, G. F., Genetics, 41, 281 (1956).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Jinks, J. L., Heredity, 9, 223 (1955).

    Article  Google Scholar 

  11. Williams, W., Nature, 184, 527 (1959).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Fisher, R. A., Proc. Boy. Soc. Edin., 42, 321 (1922).

    Article  Google Scholar 

  13. Teissier, G. C. R., Acad. Sci., Paris, 238, 621 (1954).

    CAS  Google Scholar 

  14. Wright, S., Cold Spring Harbor Symp. Quantitative Biol., 20, 16 (1955).

    Article  CAS  Google Scholar 

  15. Fisher, R. A., Amer. Nat., 64, 385 (1930).

    Article  Google Scholar 

  16. Ernst, A., Allg. Arch. J. Klaus. Stift., 8, 1 (1933).

    Google Scholar 

  17. Sheppard, P. M., Amer. Nat., 84, 283 (1953).

    Article  Google Scholar 

  18. Clarke, C. A., and Sheppard, P. M., Heredity, 14, 73 (1960).

    Article  Google Scholar 

  19. Clarke, C. A., and Sheppard, P. M., Heredity, 14, 163 (1960).

    Article  Google Scholar 

  20. Clarke, C. A., and Sheppard, P. M., Heredity, 14, 175 (1960).

    Article  Google Scholar 

  21. Mather, K., Biol. Rev., 18, 32 (1943).

    Article  Google Scholar 

  22. Mather, K., and Harrison, B. J., Heredity, 3, 1 (1949).

    Article  CAS  PubMed  Google Scholar 

  23. Thoday, J. M., and Boam, T. B., J. Genet. Res. (in the press).

  24. Gibson, J. B., and Thoday, J. M., Nature, 184, 1593 (1960).

    Article  ADS  Google Scholar 

  25. and Levene, H., Amer. Nat., 85, 247 (1951).

    Article  Google Scholar 

  26. Spiess, E. B., Cold Spring Harbor Symp. Quantitative Biol., 23, 239 (1958).

    Article  CAS  Google Scholar 

  27. Levene, H., Pavlovsky, O., and Evolution, 7, 335 (1954).

    Article  Google Scholar 

  28. Dobzhansky, Th., Cold Spring Harbor Symp. Quantitative Biol., 22, 385 (1957).

    Article  CAS  Google Scholar 

  29. Fisher, R. A., Amer. Nat., 62, 571 (1928).

    Article  Google Scholar 

  30. Fisher, R. A., Amer. Nat., 62, 115 (1928).

    Article  Google Scholar 

  31. Wright, S., Amer. Nat., 63, 274 (1929).

    Article  Google Scholar 

  32. Haldane, J. B. S., Amer. Nat., 64, 87 (1930).

    Article  Google Scholar 

  33. Harland, S. C., and Atteck, O. M., J. Genet., 42, 21 (1941).

    Article  Google Scholar 

  34. Ford, E. B., Heredity, 9, 255 (1955).

    Article  Google Scholar 

  35. Bodmer, W. F., and Parsons, P. A., Heredity, 15, 283 (1960).

    Article  Google Scholar 

  36. Kettlewell, H. B. D., Proc. Roy. Soc., B, 145, 297 (1956).

    Article  ADS  Google Scholar 

  37. Haldane, J. B. S., Proc. Roy. Soc., B, 145, 303 (1956).

    Article  ADS  Google Scholar 

  38. Haldane, J. B. S., J. Genet., 55, 511 (1957).

    Article  Google Scholar 

  39. Haldane, J. B. S., J. Genet., 37, 365 (1939).

    Article  Google Scholar 

  40. Mather, K., Symp. Soc. Exp. Biol., 7, 66 (1953).

    Google Scholar 

  41. Benzer, S., Chemical Basis of Heredity, 70 (Johns Hopkins Press, 1957).

  42. Lewis, D., Proc. Roy. Soc., B, 144, 178 (1956).

    Article  ADS  Google Scholar 

  43. Demerec, M., et al., 612 (1956).

  44. Demerec, M., and Hartman, P. E., Ann. Rev. Microbiol., 13, 377 (1960).

    Article  Google Scholar 

  45. Barratt, R. W., Newmeyer, D., Perkins, D. D., and Garnjobst, L., Adv. in Genet., 6, 1 (1954).

    Article  CAS  Google Scholar 

  46. Gross, S. R., and Fein, A., Genetics, 45, 885 (1960).

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Pardee, A. B., Jacob, F., and Monod, J., J. Mol. Biol., 1, 165 (1959).

    Article  CAS  Google Scholar 

  48. Fincham, J. B., and Pateman, J. A., Nature, 179, 741 (1957).

    Article  ADS  CAS  PubMed  Google Scholar 

  49. Giles, N. H., Partridge, C. W. H., and Nelson, N. J., Proc. U.S. Nat. Acad. Sci., 43, 305 (1957).

    Article  ADS  CAS  Google Scholar 

  50. Stern, C., and Novitski, E., Science, 108, 538 (1948).

    Article  ADS  CAS  PubMed  Google Scholar 

  51. Jinks, J. L., and Mather, K., Proc. Roy. Soc., B, 143 561 (1965).

    Article  ADS  Google Scholar 

  52. Darlington, C. D., The Evolution of Genetic Systems (Cambridg Univ. Press, 1939).

    Google Scholar 

  53. Thoday, J. M., Symp. Soc. Exp. Biol., 7, 96 (1953).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics, University of Cambridge,

    P. A. PARSONS &  W. F. BODMER

Authors
  1. P. A. PARSONS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. F. BODMER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

PARSONS, P., BODMER, W. The Evolution of Overdominance: Natural Selection and Heterozygote Advantage. Nature 190, 7–12 (1961). https://doi.org/10.1038/190007a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/190007a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing