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Clinical Application of a Serological Method for the Determination of Human Chorionic Gonadotrophin

Nature volume 189, pages 841–842 (1961)Cite this article

Abstract

IT was early observed that prolonged administration to animals of gonadotrophic hormone from human pregnancy urine was accompanied by gradually diminished effects1. This phenomenon has been found to be due to the formation of an antigonadotrophic factor demonstrable only by its capacity to impair the gonadotrophic reaction in rodents2. Previous to our earlier report3, there had been no demonstration of the antigonadotrophic factor by serological in vitro methods. Precipitating and complement-fixing antibodies had been obtained by immunization of rabbits with gonadotrophic hormone prepared from human pregnancy urine4,5. These antibodies, however, were shown to be due to contaminating, antigenically active substances6.

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynæcology, Karolinska Sjukhuset,

    SAM BRODY

  2. Gustaf Vth Research Institute, Stockholm

    SAM BRODY

  3. Department of Virus Research, Karolinska Institutet,

    GUN CARLSTRÖM

  4. Department of Bacteriology, Karolinska Sjukhuset, Stockholm

    GUN CARLSTRÖM

Authors
  1. SAM BRODY
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  2. GUN CARLSTRÖM
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BRODY, S., CARLSTRÖM, G. Clinical Application of a Serological Method for the Determination of Human Chorionic Gonadotrophin. Nature 189, 841–842 (1961). https://doi.org/10.1038/189841a0

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