Abstract
PRE-TREATMENT with diisopropylfluorophosphonate (DFP) suppresses the increase in permeability of the intestinal vessels of rats after abdominal irradiation1,2 and similar vascular changes due to other types of injury3. DFP also reduces gastrointestinal symptoms (diarrhœa), which occur after exposure to X-rays. Since death from gastrointestinal injury is one of the well-recognized forms of acute radiation death, it was decided to test the effects of DFP on rats exposed to whole-body irradiation. Twenty rats were given 975 r. whole-body X-rays with a Philips X-ray apparatus (200 kV. 15 m.amp. 0.5 mm. copper, and 1.0 mm. aluminium filters, F.S.D. 30 cm. distance); ten of these animals received a prior injection of DFP before irradiation (3.0 mgm./kgm.).
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References
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WILLOUGHBY, D. Protective Effects of Diisopropylfluorophosphonate against the Lethal Effects of X-rays before or after Irradiation. Nature 189, 761–762 (1961). https://doi.org/10.1038/189761a0
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DOI: https://doi.org/10.1038/189761a0
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