Abstract
ALTERATIONS in the amount of enzyme in a tissue can result from changes in the rate of synthesis or of destruction. The demonstration that 3-amino-1,2,4-triazole irreversibly inactivates catalase in the liver1 without interfering with its resynthesis2, and allyl-isopropyl acetamide blocks synthesis of new catalase3 suggested that these compounds might be used as tools for studying the kinetics of catalase synthesis and destruction in vivo.
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References
Margoliash, E., Novogrodsky, A., and Schejter, A., Biochem. J., 74, 339 (1960).
Sterling, W. R., Greenfield, R. E., and Price, V. E., Abst., 131st Meeting, American Chemical Society, Miami, Florida, 11C, April 7–12, 1957).
Talman, E. L., Labbe, R. F., and Aldrich, R. A., Arch. Biochem. Biophys., 66, 289 (1957).
Heim, W. G., Appleman, D., and Pyfrom, H. T., Science, 122, 693 (1955).
Greenfield, R. E., and Price, V. E., J. Biol. Chem., 220, 607 (1956).
Miller, L. L., J. Biol. Chem., 172, 113 (1948).
Greenstein, J. P., “Biochemistry of Cancer”, second ed. (Academic Press, Inc., New York, 1954).
Nakahara, W., J. Nat. Cancer Inst., 24, 77 (1960).
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PRICE, V., RECHCIGL, M. & HARTLEY, R. Methods for Determining the Rates of Catalase Synthesis and Destruction in vivo. Nature 189, 62–63 (1961). https://doi.org/10.1038/189062a0
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DOI: https://doi.org/10.1038/189062a0
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