Specific Activities of Acid-soluble Nucleotides in Hind-Leg Muscles of Mice with Dystrophia Muscularis

Abstract

IN an earlier paper¹, we showed that the concentrations of adenosine monophosphate, guanosine triphosphate and guanosine diphosphate were significantly higher in the hind limb muscles of dystrophic mice than those obtained for normal mouse muscles, while for adenosine triphosphate the reverse was found. Although the concentration of the adenosine diphosphate component was the same for both normal and dystrophic tissue, radioautographs of nucleotides containing radioactive phosphorus seemed to show an area of higher radioactivity for the adenosine diphosphate derived from the dystrophic muscle. The present work was designed to examine the turn-over rates of the acid.soluble nucleotides in the skeletal muscle of normal mice and mice afflicted with a hereditary myopathy (dystrophia muscularis).