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Structures of Some Acetyl-serine Peptides from Acetyl-chymotrypsin

Nature volume 187, pages 596–597 (1960)Cite this article

Abstract

IN 1958, two of us1 obtained, by enzymic degradation of acetyl-chymotrypsin labelled with carbon-142, five peptides containing labelled acetyl-groups. Subsequent sequence studies3 have shown that the largest of these peptides has the amino-acid sequence, Gly.Asp.Ser.Gly.Gly.Pro.Leu, identical with that already found4, by degradation of the di-isopropylphosphoryl-enzyme, to surround the reactive serine ; it may reasonably be concluded that the other four peptides contain the sequences Ser.Gly.Gly.Pro.Leu, Asp.Ser.Gly.Gly, Gly.Asp.Ser.Gly and Ser.Gly.Gly, respectively.

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References

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Authors and Affiliations

  1. Washington Singer Laboratories, The University, Exeter

    LEO BENOITON & H. N. RYDON

  2. Medical Biological Laboratory, RVO-TNO, Rijswijk Z.H., The Netherlands

    R. A. OOSTERBAAN, M. E. VAN ADRICHEM & J. A. COHEN

Authors
  1. LEO BENOITON
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  2. H. N. RYDON
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  3. R. A. OOSTERBAAN
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  4. M. E. VAN ADRICHEM
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  5. J. A. COHEN
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BENOITON, L., RYDON, H., OOSTERBAAN, R. et al. Structures of Some Acetyl-serine Peptides from Acetyl-chymotrypsin. Nature 187, 596–597 (1960). https://doi.org/10.1038/187596a0

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